Chairman Allan Maitland told the club website: “I confirm that our manager Martin Canning has left the club by mutual agreement and we will be advertising for a replacement.
“With the departure of so many important players over the last two seasons it has become increasingly difficult to maintain the playing levels and results previously reached. Martin and the Board feel that a change was necessary to give the club the best opportunity to get back to those levels.
“The club would like to thank Martin for his commitment and efforts during his ten-and-a half-years at the club as both a player and a manager. He has successfully managed to maintain our status in the Premier League and we will be forever grateful for his part in this achievement.”
The Lanarkshire club have announced that Guillaume Beuzelin and George Cairns will be in charge of first-team affairs until further notice.
Accies are 10th in the Ladbrokes Premiership table, one point ahead of Dundee – who they play on Saturday – and two in front of bottom club St Mirren.