Steven Gerrard's side earned a 1-1 draw in the Czech Republic last week thanks to a goal from Filip Helander and are favourites to reach the last eight.
This evening's match at Ibrox has an 8.00pm kick-off, with the quarter-final draw due to be made at UEFA HQ in Nyon at 12 noon on Friday.
If Rangers are successful against Slavia Prague, they will play their quarter-final matches on Thursday April 8 and Thursday April 15.