Steven Gerrard's side beat Feyenoord 1-0 at Ibrox in their opening Group G game and are in Switzerland to face Young Boys Berne, kick-off 5.55pm.
Young Boys lost 2-1 to Porto on matchday one but are unbeaten in the Swiss League and are just three points behind leaders Basel.
Neil Lennon's team started with a 1-1 draw away to Rennes in Group E and welcome CFR Cluj to Celtic Park, kick-off 8.00pm.
The Romanian side top their domestic table and beat Celtic in the Champions League qualifiers thanks to a 4-3 victory in Glasgow.