Hibernian and Kilmarnock meet in a huge game at Easter Road on Saturday lunchtime as both clubs bid to avoid being involved in the relegation play-off.
A draw will be enough to keep Killie in the Premiership but their unbroken top-flight status going back to 1993/94 will be at risk should Hibs come out on top.
In the other bottom six games - which all kick off at 12.15pm - St Mirren are up against relegated Hearts in Paisley and Partick Thistle meet Ross County at Firhill, with both teams having secured their Premiership places in midweek.
Celtic will be presented with the Scottish Premiership trophy after Sunday's game against Dundee United at Parkhead. Kick-off is 12.15pm and the game is live on Sky Sports.
Celtic need one more goal to reach a century of SPFL goals this season as they take on a United side who will be back at Celtic Park for the Scottish Cup final next weekend.
Aberdeen know a draw will be enough to see them finish in second place but victory for Motherwell at Pittodrie would see Stuart McCall's men leapfrog Derek McInnes' team. The match is live on BT Sport at 12.15pm.
The other top-six game sees Inverness CT take on St Johnstone, with the Perth club a point behind Caley Thistle in the table.