Leaders Celtic have a 12-point lead at the top of the Ladbrokes Premiership as they prepare to travel to Livingston, where they lost earlier in the season. The match is live on BT Sport with a 7.45pm kick-off.
Second-placed Rangers are at home to a Hamilton Accies side who slipped to the foot of the table on Tuesday night when Hearts beat Hibernian at Easter Road.
Motherwell, in third, host Ross County at Fir Park while Aberdeen go to Kilmarnock - the Dons have an excellent record at Rugby Park and won there in the Scottish Cup recently.
St Mirren will be looking to pull further clear of the relegation zone when they face St Johnstone in Paisley, with the visitors still harbouring hopes of a top-six place.
There's a big game in the Ladbrokes Championship between Arbroath and Dunfermline Athletic at Gayfield - the sides are separated only by goal difference and are just three points outside the play-offs.
The Ladbrokes League 2 match between Brechin City and Annan Athletic has been postponed.