Ladbrokes Premiership leaders Heart of Midlothian face Aberdeen at Tynecastle on Saturday while Celtic host Hibernian in another heavyweight clash and Rangers travel to Hamilton Accies on Sunday, live on Sky Sports at 1.30pm.
New Dundee boss Jim McIntyre takes his side to play a Livingston team unbeaten since the opening day while Motherwell are at home to St Johnstone and fourth-placed Kilmarnock go to St Mirren.
There's a top-of-the-table clash in the Ladbrokes Championship as leaders Ayr United face Ross County in Dingwall while Inverness CT put their unbeaten record on the line against Dundee United at Tannadice.
Gary Caldwell's first game as Partick Thistle manager is away to Alloa Athletic and Ray McKinnon returns to Morton with Falkirk. Dunfermline Athletic host a Queen of the South team who boast the country's top scorer in Stephen Dobbie.
Ladbrokes League 1 leaders Arbroath are four points clear as they begin the second quarter of the campaign against managerless Dumbarton while closest challengers Raith Rovers welcome Stranraer to Stark's Park. East Fife and Brechin City, both also in the top four, meet in Methil.
Bottom club Montrose play Airdrieonians at Links Park while Stenhousemuir and Forfar Athletic are separated only by goal difference as they prepare to meet at Ochilview.
There are no games in Ladbrokes League 2 this weekend as those clubs are involved in the second round of the Scottish Cup.