Curtis Main, Niall McGinn and Connor McLennan all scored in the first half for Derek McInnes' side at the Foys Stadium before Marios Ogkmpoe pulled one back late on.
The victory lifted Aberdeen above Motherwell - who are away to St Johnstone this evening - on goal difference while Accies stay a point above bottom club Hearts.
Match highlights - Hamilton Academical 1-3 Aberdeen - 11/02/20
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