Rangers host Benfica at Ibrox in Group D, kick-off 8.00pm. The Light Blues will qualify for the last 32 of the Europa League with two games to spare if they overcome the Portuguese side and Standard Liege beat Lech Poznan in Belgium.
Steven Gerrard's side remain unbeaten in all competitions this season and drew 3-3 with Benfica when the teams met in Portugal three weeks ago.
Celtic are in the Czech Republic to face Sparta Prague in Group H, kick-off 5.55pm. The Hoops need a win to keep their qualification hopes alive after losing the reverse fixture 4-1 earlier this month.
Neil Lennon's side have picked up just one point so far, from a draw away to group leaders Lille – the French outfit host AC Milan this evening.