Celtic have already booked their place in the last 32 of the Europa League in February after a dramatic 2-1 win away to Lazio on matchday four.
Neil Lennon's men are at home to Rennes this evening, kick-off 8.00pm, and will seal top spot if they beat the French side and CFR Cluj lose in Rome.
Rangers beat Porto at Ibrox last time out and could book their place in the knock-out stage with a game to spare.
Steven Gerrard's team are in Holland to play Feyenoord, kick-off 5.55pm, and will go through if they win and Porto don't beat Young Boys in Switzerland.
Both of this evening's games are live on BT Sport.
