Rangers are unbeaten in Group D and could seal their place in the last 32 of the competition when they play Standard Liege at Ibrox, kick-off 8.00pm.
Steven Gerrard's side will definitely progress if they win while a draw will be enough if Lech Poznan fail to beat Benfica in the other game.
Celtic are in Italy to play AC Milan in the San Siro, kick-off 5.55pm, but cannot reach the knock-out stage after suffering back-to-back defeats to Sparta Prague.