The match at the Global Energy Stadium is live on BBC Scotland, with a 7.05pm kick-off.
The Staggies know a point will be enough to clinch promotion back to the Premiership at the first time of asking while Queens are embroiled in a battle to avoid relegation.
Queen of the South won the last meeting 4-0 at Palmerston in January, with the other two encounters this season both ending in draws.
