Killie have won both Premiership meetings this season - 2-1 in Paisley in October and 2-1 at Rugby Park in December.
Kilmarnock are fourth, above Hearts on goal difference, but are seeking their first win since beating Rangers on January 23.
St Mirren are bottom of the table but are unbeaten in their last three matches and a draw would be enough to take them above Dundee.