Steven Gerrard's side recovered from the loss of an early goal to lead 3-1 thanks to an own goal, Glen Kamara and Alfredo Morelos, who is now the club's record scorer in European football.
Rangers are level on seven points with group leaders Benfica, who visit Ibrox for matchday four on Thursday November 26.
In Group H, Celtic suffered a 4-1 home defeat to Sparta Prague and now face an uphill task if they are to reach the knock-out stage.
