The weekend action gets under way on Friday night when Kilmarnock welcome Ladbrokes Premiership leaders Rangers to Rugby Park, live on BT Sport at 7.45pm.
There's a big game at Parkhead on Saturday as reigning champions Celtic, with two wins out of two, face unbeaten Aberdeen, who were runners-up last term.
Ross County, who sit third in the table, make the trip to the SuperSeal Stadium to take on Hamilton Accies while Partick Thistle and Hearts meet at Firhill.
Motherwell are aiming to leapfrog Dundee with a victory at Fir Park while Inverness CT are seeking their first points of the season against St Johnstone at the Tulloch Caledonian Stadium.
In the Ladbrokes Championship, leaders Raith Rovers put their 100% record on the line against Dundee United at Tannadice and Hibernian are also aiming to make it four wins out of four against Morton at Easter Road.
Queen of the South, who are two points off the pace, travel to Dunfermline and Falkirk are looking for their first victory of the campaign at home to Dumbarton. Bottom club Ayr United take on St Mirren at Somerset Park.
Livingston are the leaders in Ladbrokes League 1 and head for Hampden to face Queen's Park, having won three games out of three.
They are ahead of Alloa Athletic on goal difference - the Wasps have a 100% record in league and cup and are away to Albion Rovers on Saturday.
Unbeaten Brechin City, who are third, travel to Methil to take on East Fife while fourth-placed Airdrieonians head to Stenhousemuir.
Peterhead make the long journey south to Stranraer, with both clubs aiming to improve on disappointing starts to the season.
It's first against second in Ladbrokes League 2 as Forfar Athletic, with three wins out of three, host Elgin City at Station Park.
Annan Athletic, in third spot after two good home wins, travel to Montrose while unbeaten Arbroath welcome Stirling Albion to Gayfield.
Clyde are up against Cowdenbeath at Broadwood and bottom club Edinburgh City are aiming to get off the mark against Berwick Rangers at Meadowbank Stadium.