The weekend action gets under way on Friday night when Dundee welcome Hamilton Accies to Dens Park in the Ladbrokes Premiership.
Leaders Rangers are at home to Motherwell on Saturday, with second-placed St Johnstone taking on Celtic in the early game at McDiarmid Park, live on BT Sport with a 12.15pm kick-off.
Aberdeen, who have drawn both games 0-0, welcome Partick Thistle to Pittodrie and Heart of Midlothian take on an Inverness Caley Thistle side still looking for their first point. Ross County and Kilmarnock - with a win apiece from their opening two matches - meet in Dingwall.
The stand-out fixture in the Ladbrokes Championship sees leaders Raith Rovers welcome local rivals Dunfermline Athletic to Stark’s Park for a big Fife derby.
Hibernian, who are second on goal difference, travel to Paisley to play St Mirren, while Queen of the South will aim to continue their good start when they face Falkirk at Palmerston.
Morton, with two draws to date, host a Dumbarton side who shocked Dundee United last weekend. Ray McKinnon's United are this week at home to an Ayr United side seeking their first point since winning promotion.
Ladbrokes League 1 pacesetters Alloa Athletic put their 100% record in league and cup on the line at the Indodrill Stadium against an East Fife team who have also started the season well.
Livingston, in second spot on goal difference, entertain a Stenhousemuir side who have lost two out of two but beat Rangers U20s in the IRN-BRU Cup.
Brechin City, who are in third place, meet promoted Queen's Park at Glebe Park while Airdrieonians and Stranraer go head to head at the Excelsior Stadium.
Peterhead and Albion Rovers are seeking their first league win of the season when they meet at Balmoor but both were boosted by midweek wins in the IRN-BRU Cup.
Elgin City are the early leaders in Ladbrokes League 2 and will seek to make it three wins out of three against an Arbroath side who travel to Borough Briggs on the back of two 1-1 draws.
It's third against second at Shielfield as Berwick Rangers host Forfar Athletic while title favourites Clyde go to Galabank to take on Annan Athletic.
Cowdenbeath and Edinburgh City have both lost twice as they prepare to meet at Central Park while Stirling Albion and Montrose are bidding for their first league victory of the season as they clash at Forthbank.